Extraction of Erythropoietin from Kidneys of Hypoxic and Phenylhydrazine-treated Rats.
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Extraction of Erythropoietin from Kidneys of Hypoxic and Phenyihydrazine-Treated Rats
By JOSEPH F. CONTRERA, JAMES F. CA IIsCoLI, ARTHUR H. WEINTRAUB AND ALBERT S. GORDON T HE CONTENTION that the kidney is a major site of erythropoietin ( ESF ) production or activation is well supported.’4 Several attempts have been made to extract ESF from kidneys of anemic and normal anirnals.5#{176} Renal homogenates obtained at neutral pH from both anemic and normal dogs,5 rabbits,6 or rats7...
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Immunoreactive erythropoietin (Ep) was measured in normoxic and hypoxic (0.5 atm; 18 hours) fetal rats from day 14 to day 21 of gestation and in neonatal rats from birth to weaning, and was compared to the adult rat. Amniotic fluid (AF) Ep was approximately 100 mU/mL on day 14 and 15, and decreased to 20 mU/mL on day 20, with no difference between the hypoxic and normoxic mothers. Only on day 2...
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Significant increases in the serum erythropoietin of male rats occur after the end of a brief hypoxic exposure. These increases in the hormone are almost completely abolished when the kidneys are removed after the hypoxic exposure. Injection of puromycin or cycloheximide after the hypoxic exposure significantly decreases the subseauent increases in serum erythropoietin titers, whereas injection...
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Background: Artichoke (Cynara scolymus) possesses bioactive components with antioxidant effects. This plant has been widely used in traditional medicine. Objectives: The current study aimed to examine the protective activity of Hydroethanolic Extract of Cynara scolymus (HECS) against experimentally-induced hemolytic anemia in rats. Methods: Hemolytic anemia was induced by intraperitoneal inj...
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Erythropoiesis in spleens of lethally irradiated Lewis rats grafted with 4-35 X 10(6) syngeneic marrow cells was inhibited or delayed during the test period of 5 days; this was in marked contrast to observation in irradiated mice. The mechanism of this inhibition was the subject of this study. Pretreatment of recipients 9 days prior to irradiation with the cytotoxic drugs cyclophosphamide (CY),...
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عنوان ژورنال:
- Blood
دوره 25 شماره
صفحات -
تاریخ انتشار 1965